Relationship between integral marker of metabolic status Lipid Accumulation Product (LAP) index and vascular stiffness

Tóm tắt

Background

To evaluate the lipid accumulation product (LAP) index correlation with anthropometric measurements and markers of vascular stiffness (ankle-brachial index (ABI), cardio-ankle vascular index (CAVI) and vascular aging (VA)).

Methods

193 patients (72 men и 121 women) were examined, age median was 36,5 [21;56] years. All participants underwent anthropometric measurement and lipid profile test (total cholesterol (TC), lipoproteins and triglycerides (TG)) by CardioChek PA (USA) express analyzer. The LAP index was calculated by the formula: (LAP = (WC (cm) – 65) x TG (mmol/L)) for men, and (LAP = (WC (cm) – 58) x TG (mmol/L)) for women. Vascular stiffness level (ABI, CAVI, VA indices) was measured by sphygmomanometry on VaSera FUCUDA DENSHI scanner (Japan). Statistical processing of the data was done with STATISTICA 10 software.

Results

Included patients were divided into two groups according to the presence and absence of metabolic syndrome (MS). In the group 1 were patients with MS (n=35), median age was 38,7 [26;62] years. In the group 2 were patients without MS (n=158), median age was 30 [21;52] years. The groups had no statistical difference by gender and age (p>0,05). In the group 1 body mass index (BMI) (33,3[31;35]), waist circumference (WC) (110[98;120]), systolic blood pressure (SBP) (137[130;149]), diastolic blood pressure (DBP) (83[75;90]), glucose level (5,8[5,1;6,6]), TC (5,3[4;6,6]) were significantly higher than in the group 2  (BMI 24,6[21;28], WC 78[69;87], SBP 127[120;135], DBP 80[72;85], glycose level 4,8[4,4;5,7], TC 4,6[4;5,5] (p<0,05).

In the group 1 the LAP index (88,2[44;134] cm×mmol/L), was significantly higher, than in the group 2 (25,7[12,4;48,8] cm×mmol/L), (p<0,01).

In the group 1 CAVI 8,8[7,8;9,8], ABI 0,97[0,91;1,2] and VA 68[55;80] indices had no significant difference from participants in the group 2: CAVI 6,6[5,9;7,6], ABI  1,08[1,02;1,21] and VA 25[20;51], (p<0,05).

We have found significant correlation between the LAP index and age (r=0,29;p<0,05), obesity (r=0,6;p<0,05), MS (r=0,44;p<0,05), BMI (r=0,74;p<0,05), WC (r=0,83;p<0,05), SBP (r=0,35;p<0,05), DBP (r=0,22;p<0,05), TC (r=0,2;p<0,05), glycose level (r=0,3;p<0,05), CAVI (r=0,2;p<0,05) and VA (r=0,2;p<0,05).

Conclusion

The LAP-index has higher values for patients with metabolic syndrome. This integrative metabolic index associated with anthropometric measurements, cardiometabolic biomarkers, systolic and diastolic blood pressure and markers of vascular stiffness – CAVI and vascular aging.